The recent launch of Shenzhou-20, carrying six zebrafish to the Chinese space station, highlights the growing intersection between space exploration and biological research. This matters because understanding how life adjusts to extreme environments—like microgravity—can mitigate health risks for astronauts and inform future deep space missions. As humanity looks to venture beyond Earth, research into how organisms adapt and survive becomes increasingly crucial.

Zebrafish, which share a significant genetic resemblance to humans (70-80%), are an exemplary model organism. In their unique transparent embryos, scientists are studying bone loss and heart muscle remodeling induced by the microgravity environment of space. This model offers a simplified yet profound way to observe complex biological processes without the ethical and practical concerns associated with human experimentation. Beyond zebrafish, organisms like fruit flies, mice, and yeast have long been pivotal in various fields, from genetics to cancer research, demonstrating how model organisms can unlock secrets of life.

The adoption of multiple model organisms is becoming a trend in contemporary life sciences. Each species, while advantageous in certain aspects, has limitations that can skew results. For instance, while fruit flies are ideal for genetic studies, they cannot mimic mammalian immune responses. By employing diverse species, researchers can validate findings across systems, enhancing the robustness and applicability of their conclusions. This multi-model approach not only deepens our understanding of fundamental life processes but also enhances the translational potential of research from bench to bedside.

In summary, as we push the boundaries of scientific knowledge from our planet into the cosmos, model organisms serve as indispensable tools in our quest to unlock life's mysteries. Their unique characteristics allow us to conduct vital research under controlled conditions. With the increasing complexity of biological questions, the strategy of using multiple model systems will likely yield more comprehensive insights into health and disease. How will advancements in these research paradigms shape the future of human exploration in space?